Buy Colcrys (Colchicine) Online
So, in rural areas 4-5% of Colchicine pills is infested with balantidia. Persons in contact with pigs, which are natural carriers of balantidia, are especially often infected. In the foci, infection can occur through contact with patients with balantidiasis. Diseases occur, as a rule, in the form of sporadic cases. Pathogenesis (what happens?) during Balantidiasis.
The natural carriers of balantidia are pigs. Infection of a person occurs when balantidia, more often cysts, enter the digestive tract. The causative agent can exist for a long time in the human intestine without showing a pathogenic effect. It usually lives in the lower parts of Colchicine pills intestines. The reasons for the introduction of balantidia into the intestinal tissue, which is observed only in a small part of the infested, remain unexplored. Lesions caused by balantidia are localized mainly in the blind, sigmoid and rectum.
Colchicine Oral capsule
Initially, areas of edema and hyperemia appear on the folds of the mucous membrane, then erosions form, balantidia penetrate into the thickness of the tissues, causing foci of hemorrhages and necrosis. After rejection of necrotic masses, a cavity remains that communicates with the intestinal lumen. The ulcers have irregular outlines, the edges are indented and thickened, the bottom is uneven, covered with a bloody-purulent coating. Perforation of ulcers may occur with the development of diffuse peritonitis.
Clinically, balantidiasis can occur in acute and chronic forms.
There are also latent balantidiasis (carriage) and combined forms of balantidiasis (with amoebiasis, shigellosis, etc.). The severity of the course is dominated by moderate and severe forms. Acute forms of balantidiasis resemble enterocolitis or colitis in their manifestations. Symptoms of general intoxication appear: weakness, headache, loss of appetite, half of the patients have moderate fever, sometimes with chills.
At the same time, signs of intestinal damage are observed: abdominal pain, diarrhea, flatulence, with involvement of the rectum, tenesmus is possible. In the feces there may be impurities of mucus and blood. Quite often note the dry coated language, a spasm and morbidity of a large intestine, the liver is enlarged and painful. Sigmoidoscopy reveals a focal infiltrative-ulcerative process.
In the blood hypochromic anemia, neutrophilic leukocytosis.
In the study of blood - moderate anemia, eosinophilia, a decrease in the total amount of protein and albumin, ESR is moderately increased. In severe acute balantidiasis, there is a high fever, symptoms of intoxication are pronounced (chills, nausea, vomiting, headache). Stool up to 20 times a day with an admixture of mucus and blood, with a putrid odor. Patients quickly lose weight, cachexia may develop in a week. There may be signs of peritoneal irritation. Sigmoidoscopy reveals extensive ulcerative changes.
Acute balantidiasis Acute forms of the disease are characterized by fever, symptoms of general intoxication and signs of intestinal damage (abdominal pain, diarrhea, flatulence, tenesmus is possible - false urge to defecate). In the stool there is an admixture of mucus and blood.
Spasm and soreness of the large intestine, enlargement of the liver are characteristic. Sigmoidoscopy reveals a focal infiltrative-ulcerative process. In severe cases, general intoxication, high fever, stools up to 20 times a day with an admixture of mucus and blood with a putrid odor are noted. Patients quickly lose weight, sometimes there are symptoms of irritation of the peritoneum. With sigmoidoscopy, extensive ulcerative lesions are established.
Chronic balantidiasis In chronic balantidiasis, the symptoms of intoxication are mild, body temperature is normal, stools are up to 2-3 times a day, liquid, with mucus, sometimes with an admixture of blood. When probing, pain is noted mainly in the area of \u200b\u200bthe blind and ascending colon. With sigmoidoscopy, there may be typical ulcerative changes. The diagnosis is confirmed by the presence of parasites in the stool.
The diagnosis of balantidiasis is made on the basis of the detection of balantidia in native smears from feces or scrapings from the affected areas of the intestinal mucosa taken during sigmoidoscopy. Due to their large size, mobility, characteristic shape and the presence of a contractile vacuole, balantidia are easily recognized. Their cysts, which are extremely rare in the human intestine, can sometimes be found in preparations stained with Lugol's solution.
For the diagnosis, information about the residence of patients in rural areas and their contact by occupation with pigs is important. In some cases, a small amount of balantidia is excreted with feces and they can be detected in smears only with repeated multiple analyzes or when sown on nutrient media.
In a native smear, vegetative forms of balantidia can be detected, the length of which is on average 75 microns, and the width is 40 microns. They move very quickly, easily changing the shape of the body and rotating around the longitudinal axis. Therefore, to identify them, it is more convenient to use a low magnification of the microscope.
If it is necessary to examine the balantidia in more detail, under high magnification (10x40), then their movement should be slowed down, sucking out excess liquid from the preparation. Such preparations show that the body of the balantidia is ovoid in shape, its anterior narrower end is somewhat flattened. The entire surface of the body is covered with longitudinal rows of cilia, the flickering of which is clearly visible along the edges of the cell. At the front end or somewhat on the side, a funnel-shaped depression - a pinnate - is noticed.
The cytoplasm is thinly dividedthe surface layer, strongly refracting light - ectoplasm and the inner cloudy granular opaque mass - endoplasm. Against the background of the endoplasm in the center of the body or closer to one of its ends, one can sometimes see a light large bean-shaped vegetative nucleus - the macronucleus. Contractile vacuoles in the form of appearing and disappearing light balls are located in the anterior and posterior parts of the body. The endoplasm of the parasite also contains various food particles: swallowed erythrocytes, starch grains, fungi, bacteria enclosed in digestive vacuoles.